NMR insights into protein allostery
Identifieur interne : 002549 ( Main/Exploration ); précédent : 002548; suivant : 002550NMR insights into protein allostery
Auteurs : Gregory Manley [États-Unis] ; J. Patrick Loria [États-Unis]Source :
- Archives of biochemistry and biophysics [ 0003-9861 ] ; 2011.
Abstract
Allosterism is one of nature's principal methods for regulating protein function. Allosterism utilizes ligand binding at one site to regulate the function of the protein by modulating the structure and dynamics of a distant binding site. In this review, we first survey solution NMR techniques and how they may be applied to the study of allostery. Subsequently, we describe several examples of application of NMR to protein allostery and highlight the unique insight provided by this experimental technique.
Url:
DOI: 10.1016/j.abb.2011.10.023
PubMed: 22198279
PubMed Central: 4086649
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000066
- to stream Pmc, to step Curation: 000066
- to stream Pmc, to step Checkpoint: 000057
- to stream Ncbi, to step Merge: 000125
- to stream Ncbi, to step Curation: 000123
- to stream Ncbi, to step Checkpoint: 000123
- to stream Main, to step Merge: 002591
- to stream Main, to step Curation: 002549
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">NMR insights into protein allostery</title><author><name sortKey="Manley, Gregory" sort="Manley, Gregory" uniqKey="Manley G" first="Gregory" last="Manley">Gregory Manley</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Chemistry, Yale University, 225 Prospect Street, P.O. Box 208107, New Haven CT 06520-8107</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Chemistry, Yale University, 225 Prospect Street, P.O. Box 208107</wicri:cityArea></affiliation></author><author><name sortKey="Loria, J Patrick" sort="Loria, J Patrick" uniqKey="Loria J" first="J. Patrick" last="Loria">J. Patrick Loria</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Chemistry, Yale University, 225 Prospect Street, P.O. Box 208107, New Haven CT 06520-8107</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Chemistry, Yale University, 225 Prospect Street, P.O. Box 208107</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Molecular Biophysics and Biochemistry, Yale University, 225 Prospect Street, P.O. Box 208107, New Haven CT 06520-8107</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Molecular Biophysics and Biochemistry, Yale University, 225 Prospect Street, P.O. Box 208107</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22198279</idno><idno type="pmc">4086649</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086649</idno><idno type="RBID">PMC:4086649</idno><idno type="doi">10.1016/j.abb.2011.10.023</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000066</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000066</idno><idno type="wicri:Area/Pmc/Curation">000066</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000066</idno><idno type="wicri:Area/Pmc/Checkpoint">000057</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000057</idno><idno type="wicri:Area/Ncbi/Merge">000125</idno><idno type="wicri:Area/Ncbi/Curation">000123</idno><idno type="wicri:Area/Ncbi/Checkpoint">000123</idno><idno type="wicri:doubleKey">0003-9861:2011:Manley G:nmr:insights:into</idno><idno type="wicri:Area/Main/Merge">002591</idno><idno type="wicri:Area/Main/Curation">002549</idno><idno type="wicri:Area/Main/Exploration">002549</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">NMR insights into protein allostery</title><author><name sortKey="Manley, Gregory" sort="Manley, Gregory" uniqKey="Manley G" first="Gregory" last="Manley">Gregory Manley</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Chemistry, Yale University, 225 Prospect Street, P.O. Box 208107, New Haven CT 06520-8107</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Chemistry, Yale University, 225 Prospect Street, P.O. Box 208107</wicri:cityArea></affiliation></author><author><name sortKey="Loria, J Patrick" sort="Loria, J Patrick" uniqKey="Loria J" first="J. Patrick" last="Loria">J. Patrick Loria</name><affiliation wicri:level="2"><nlm:aff id="A1">Department of Chemistry, Yale University, 225 Prospect Street, P.O. Box 208107, New Haven CT 06520-8107</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Chemistry, Yale University, 225 Prospect Street, P.O. Box 208107</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2">Department of Molecular Biophysics and Biochemistry, Yale University, 225 Prospect Street, P.O. Box 208107, New Haven CT 06520-8107</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Connecticut</region></placeName><wicri:cityArea>Department of Molecular Biophysics and Biochemistry, Yale University, 225 Prospect Street, P.O. Box 208107</wicri:cityArea></affiliation></author></analytic><series><title level="j">Archives of biochemistry and biophysics</title><idno type="ISSN">0003-9861</idno><idno type="eISSN">1096-0384</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Allosterism is one of nature's principal methods for regulating protein function. Allosterism utilizes ligand binding at one site to regulate the function of the protein by modulating the structure and dynamics of a distant binding site. In this review, we first survey solution NMR techniques and how they may be applied to the study of allostery. Subsequently, we describe several examples of application of NMR to protein allostery and highlight the unique insight provided by this experimental technique.</p></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Connecticut</li></region></list><tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Manley, Gregory" sort="Manley, Gregory" uniqKey="Manley G" first="Gregory" last="Manley">Gregory Manley</name></region><name sortKey="Loria, J Patrick" sort="Loria, J Patrick" uniqKey="Loria J" first="J. Patrick" last="Loria">J. Patrick Loria</name><name sortKey="Loria, J Patrick" sort="Loria, J Patrick" uniqKey="Loria J" first="J. Patrick" last="Loria">J. Patrick Loria</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Lorraine/explor/InforLorV4/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002549 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002549 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Lorraine
|area= InforLorV4
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4086649
|texte= NMR insights into protein allostery
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22198279" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a InforLorV4
| This area was generated with Dilib version V0.6.33. |  |